The level of erythrocyte protoporphyrin is used as a screening test → at values > 350 μg/l, it is necessary to determine the lead concentration in venous blood, clinical symptomatology develops at values > 700 μg/l, but anemia can appear already at a value > 250 μg/l.

another target organ is the kidneys, where tubular functions are damaged.

severe poisoning can result in encephalopathy with brain edema, convulsions and impaired consciousness,.

Moderate poisoning is manifested by anorexia, fatigue, irritability, constipation and occasional abdominal pain,.

Interferes with heme synthesis by inhibiting erythrocyte ATPase synthesis, inhibits cholinergic functions and causes degeneration of Schwann cells → leading to demyelination.

Lead damages the organism through several mechanisms. Excretion is very slow with a half-life of about 20 years! Pathogenesis The source of organic lead is mainly leaded gasoline.Ībsorbed lead binds to erythrocytes and is distributed to target organs → liver, kidneys, brain, bones. Inorganic lead is found in soil, dust, battery cells, pottery glazes and lead paint. the complex is excreted in urine → cannot be used in case of alteration of renal functions.Ī piece of lead Pharmacology.is it ineffective in Hg, As, Au poisoning,.Forms chelates with extracellular lead,.is the drug of choice for poisoning with organic mercury compounds.Ĭalcium disodium versenate CaNa 2EDTA.then we continue according to the levels of noxy,.á 8 hours during 5 days, then at an interval of 12 hours, It is administered in asymptomatic child poisonings,.administration of iron is contraindicated because a toxic complex is formed.primarily excreted in the bilee → is the drug of choice for renal function impairment and poisoning with inorganic mercury compounds,.is ineffective with a large amount of heavy metal,.dimercaptopropanol forms complexes with intracellular and extracellular Pb, As, Hg, Au,.We dose 5 mg/kg – 6x during the 1st day, 3x on the 2nd day, then 1–2x, we continue according to the concentration of nox in the blood and urine,.hair: > 1 μg/kg – indicator of chronic poisoning.urine: > 100 μg/l – indicator of acute poisoning.> 250 μg/l – laboratory toxic concentration,.Laboratory diagnosis of heavy metal poisoning Lead 2.3 Calcium disodium versenate CaNa 2EDTA.1 Laboratory diagnosis of heavy metal poisoning.

Lead poisoning antidote